Protein Modification Reagents
Medchemexpress LLC (S,R,S)-AHPC-PEG5-Boc | 2923734-82-9 | 95.3% | 807.01 g/mol | C40H62N4O11S | 5 MG
(S,R,S)-AHPC-PEG5-Boc is an E3 ligase ligand-linker conjugate that combines an (S,R,S)-AHPC-derived VHL ligand with a PEG5 spacer and a Boc protecting group. It is designed for use in targeted protein degradation research and PROTAC synthesis, and is supplied at high purity for medicinal chemistry applications. CAS 2923734-82-9, molecular weight 807.01 g/mol, purity ≈95.3%.
- Boc-protected VHL ligand-linker conjugate suitable for PROTAC development.
- Peg5 linker provides flexible spacing for bifunctional molecule design.
- High purity supports medicinal chemistry and analytical work.
- Available in small mass quantities to support discovery research.
- Soluble in DMSO for convenient formulation and handling.
- Stable when stored cold under inert atmosphere for longer-term storage.
Medchemexpress LLC DBCO-PEG4-NHS ester | 1427004-19-0 | 99.0% | C34H39N3O10 | 500 MG
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC)
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 5 G
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is for research use only and not sold to patients.
- Appears as a colorless to light yellow liquid with a density of 1.473 g/cm³.
- PROTACs consist of two different ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest.
- PROTACs work by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC DBCO-PEG24-NHS ester | 2765066-38-2 | MFCD34551889 | 95.5% | 1530.74 | C74H119N3O30 | 10 MG
DBCO-PEG24-NHS ester is a bifunctional polyethylene glycol (PEG) reagent containing a dibenzocyclooctyne (DBCO) group and an N-hydroxysuccinimide (NHS) ester. It is designed for bioconjugation workflows where copper-free click chemistry and selective amine coupling are required; the PEG24 spacer increases water solubility and reduces steric hindrance. Supplied for research use with documented purity and recommended storage conditions.
- Enables copper-free click chemistry via DBCO-mediated SPAAC.
- Reacts selectively with primary amines through NHS ester chemistry.
- Provides a PEG24 spacer to increase water solubility and flexibility.
- Supplied with documented purity and certificate of analysis.
- Stable when stored sealed, away from moisture and light under recommended temperatures.
- Available in small research-scale quantities.
Bioworld D(+) Galactose, 500 g
An monosaccharidic aldo hexose potentially useful in aging studies. Specifications:High Purity GradeSpecific Rotation (2% water): 79 - 81°Appearance: White PowderBoiling Point : 410.8 °CDensity : 1.5 g/cm3HS Code : 29400090Melting Point: 168-170 °CRTECS Number: LW5490000
Broadpharm DBCO-PEG8-NHS ester, 50mg
Formula: C42H55N3O14, Purity: 98%, MW: 825.9, DBCO-PEG8-NHS Ester is a PEG derivative containing an NHS ester moiety that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.
Medchemexpress LLC Pomalidomide-5'-PEG5-C2-COOH | 2412056-50-7 | 98.1% | 565.57 | 50 MG
Pomalidomide-5'-PEG5-C2-COOH is an active compound used for the research of various biochemical applications.
- Active compound
- Can be used for research of various biochemical applications
- Store at -20°C, protected from light, and under nitrogen
- Soluble in DMSO
- Molecular formula C26H35N3O11
- Purity of 98.1%
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2835.50 g/mol | C149H224N22O32 | 100 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate and click-chemistry reagent used for preparing antibody-drug conjugates and other azide-based bioconjugates. It combines a DBCO clickable handle, a PEG2 spacer, a Val-Cit protease-cleavable dipeptide, a PAB self-immolative spacer, and an MMAE cytotoxic payload.
- Provides strain-promoted alkyne-azide cycloaddition (SPAAC) reactivity for conjugation to azide-tagged molecules.
- Val-Cit linker enables protease-mediated intracellular release of the MMAE payload.
- Supplied with analytical documentation, including HNMR, RP-HPLC, MS, COA, and SDS.
- Available in multiple pack sizes, including a 100 mg quantity for preparative use.
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 50 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Purity of 97.0%
Medchemexpress LLC N-(4-hydroxyphenethyl)pent-4-ynamide | 1694495-59-4 | 99.7% | C13H15NO2 | 10MG
Alkyne-phenol is an alkyne-containing click-chemistry probe for proximity labeling with ascorbate peroxidase (APEX2). It is more cell wall-permeant than biotin-phenol, improving labeling efficiency in intact cells, and enables identification of APEX-labeled sites for membrane topology assignment and proteomic analysis.
- Improves APEX-labeling efficiency in intact cells.
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- More cell wall-permeant than biotin-phenol.
- Aids identification of labeling sites and membrane topology assignment.
- Available as a solid and as a 10 mM solution in DMSO.
- High purity (99.7%).
Medchemexpress LLC TCO-PEG5-maleimide | 00-00-0 | 99.5% | 583.67 g/mol | C28H45N3O10 | 5 MG
TCO-PEG5-maleimide is a PEG-based PROTAC linker and click-chemistry reagent containing a trans-cyclooctene (TCO) group that reacts via inverse electron-demand Diels-Alder (iEDDA) with tetrazine-functionalized partners. It also features a maleimide moiety for thiol conjugation and is supplied as a high-purity solid in small research pack sizes.
- Contains a trans-cyclooctene (TCO) reactive group for inverse electron-demand Diels-Alder (iEDDA) click reactions.
- Includes a PEG5 spacer to enhance solubility and linker flexibility.
- Features a maleimide group for selective conjugation to thiol groups.
- Offered as high-purity material (reported ~99.5%).
- Available in small milligram pack sizes suitable for research use.
- Store sealed at -20°C; in solvent, store at -80°C for long-term stability.
eMolecules 139115-89-2 | Ms-PEG4 | Broadpharm | MFCD22574814 | 228.260 | C7H16O6S | 98.000 | CS(=O)(=O)OCCOCCOCCO | 1g | 112541219
Ms-PEG4 | Broadpharm | 139115-89-2 | MFCD22574814 | 228.260 | C7H16O6S | 98.000 | CS(=O)(=O)OCCOCCOCCO | 1g | 112541219
Medchemexpress LLC Dnp-peg4-dbco | 2149585-17-9 | MFCD31654037 | 97.0% | C35H39N5O10 | 10MG
DNP-PEG4-DBCO is a PEG-based PROTAC linker and click-chemistry reagent that combines a dinitrophenyl (DNP) moiety with a dibenzocyclooctyne (DBCO) group. The DBCO enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, supporting efficient bioconjugation and PROTAC assembly.
- Contains DNP and DBCO functional groups for dual reactivity.
- Enables copper-free SPAAC click chemistry with azide partners.
- Suitable for PROTAC linker synthesis and bioconjugation workflows.
- High purity (97.0%) for reliable analytical and preparative use.
- Stable under recommended storage conditions for extended shelf life.